Citrulline metabolism in normal and citrullinemic human lymphocyte lines
نویسندگان
چکیده
منابع مشابه
Argininosuccinate synthetase activity and citrulline metabolism in cells cultured from a citrullinemic subject.
Citrullinemia-is one of several human diseases caused by a defect in the KrebsHenseleit urea cycle. In this disorder a deficiency of liver argininosuccinate synthetase has been reported.' 1\Iorrow and his colleagues have recently described an infant with this condition2 and a fibroblast-like cell line has been derived from a skin biopsy of this child. In studying minimal media requirements for ...
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Citrulline possesses a highly specific metabolism that bypasses splanchnic extraction because it is not used by the intestine or taken up by the liver. The administration of citrulline may be used to deliver available nitrogen for protein homeostasis in peripheral tissues and as an arginine precursor synthesized de novo in the kidneys and endothelial and immune cells. Fresh research has shown t...
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ژورنال
عنوان ژورنال: Biochemical Genetics
سال: 1975
ISSN: 0006-2928,1573-4927
DOI: 10.1007/bf00485789